About Rosuvastatin :

1. Hypolipidemic effect
Rovastatin significantly reduced blood lipid, general statin to reduce low-density lipoprotein cholesterol (LDL-C) level of 17% to 54%. The results of the phase Ⅱ clinical trial of rosuvastatin showed that LDL-C was reduced to 65% at the dose of 80 mg, which is the best effect of statins. Rovastatin may increase the number of LDL receptors. In human hepatoma, rosuvastatin increased the amount of LDL receptor mRNA about 10 times more than pravastatin.
2. Selective effects on liver cells
Hepatocyte-derived cholesterol is the main cause of the formation of blood cholesterol, and cholesterol derived from non-hepatocytes is essential for normal cells. The main site of action of lovastatin is the liver, from the inhibition of sterol synthesis, the drug on the rat liver selectivity than the peripheral tissue selectivity, and than pravastatin or simvastatin on liver tissue selection Sex should be high. Through the active absorption process, rosuvastatin is absorbed into the liver cells, which in liver cells in the inhibition of cholesterol than 1000 times higher in fibroblasts.
3. anti-atherosclerotic effect
Rovastatin can reduce blood lipids, reduce lipid infiltration and foam cell formation, delayed atherosclerosis beneficial; the drug can also block the hydroxymethyl glutaric acid pathway, in particular the inhibition of isoprenoid metabolites Formation and inhibition of smooth muscle cell proliferation and promote apoptosis and stabilize atherosclerotic plaques, delay the occurrence of atherosclerosis, development.

 

 

Uses	For making lipid-lowering drugs.
Chemical Properties	White to Off-White Crystalline Solid
Usage	A selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
Usage	antiinflammatory, glucocorticoid
Usage	antirheumatic

 

 

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