61825-94-3 GMP API Anticancer Chemical Oxaliplatin Powder For Colorectal Cancer

61825-94-3 GMP API Anticancer Chemical Oxaliplatin Powder For Colorectal Cancer

Introduction

Oxaliplatin, marketed as Eloxatin by Sanofi, is a platinum-based antineoplastic agent used in cancer chemotherapy.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.

Medical Uses

Oxaliplatin is used for treatment of colorectal cancer, typically along with folinic acid and 5-fluorouracil in a combination known as FOLFOX. Oxaliplatin has been compared with other platinum compounds used for advanced cancers, such as cisplatin and carboplatin.

Side Effects

Side-effects of oxaliplatin treatment can potentially include:

• Neurotoxicity leading to chemotherapy-induced peripheral neuropathy, a progressive, enduring and often irreversible tingling numbness, intense pain and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs, often with deficits in proprioception.
• Fatigue
• Nausea, vomiting, or diarrhea
• Neutropenia (low number of a type of white blood cells)
• Ototoxicity (hearing loss)
• Extravasation if oxaliplatin leaks from the infusion vein it may cause severe damage to the connective tissues.
• Hypokalemia (low blood potassium), which is more common in women than men[8]
• Persistent hiccups
• Rhabdomyolysis
• In addition, some patients may experience an allergic reaction to platinum-containing drugs. This is more common in women.
• Oxaliplatin has less ototoxicity and nephrotoxicity than cisplatin and carboplatin.

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