CAS 102767-28-2 Pharmaceutical Raw Materials API Ticagrelor Intermediate

CAS 102767-28-2 Pharmaceutical Raw Materials API Ticagrelor Intermediate

Appearance Off- white crystalline powder

Related impurity Single impurity ≤0.5%
Total impurities ≤1.0%
Purity ≥99.5%

Ticagrelor Intermediate

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Ticagrelor is used for:

1.Reducing the risk of stroke, heart attack, or death in certain patients who have had a heart attack or who have angina (chest pain). It should be used along with aspirin as directed by your doctor. It also may be used for other conditions as determined by your doctor.

2.Ticagrelor is a platelet aggregation inhibitor. It works by slowing or stopping platelets from sticking to blood vessel walls or injured tissues.

Do NOT use ticagrelor if:

• you are allergic to any ingredient in ticagrelor
• you have an active bleeding problem (eg, bleeding stomach ulcer, bleeding in the brain) or a history of bleeding in the brain
• you have severe liver problems
• you are taking certain azole antifungals (eg, itraconazole, ketoconazole, voriconazole), carbamazepine, dexamethasone, certain macrolide antibiotics (eg, clarithromycin), nefazodone, phenobarbital, phenytoin, certain protease inhibitors (eg, atazanavir, ritonavir), rifampin, or telithromycin

Before using ticagrelor:

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver or kidney problems, lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease [COPD]), recent stomach or bowel bleeding, or a history of ulcers or bowel polyps
• if you have had a recent injury or surgery, including dental surgery; if you will be having surgery or a dental procedure; or if you are on dialysis
• if you have certain irregular heartbeat problems (eg, sick sinus syndrome, second- or third-degree heart block), or you have fainting caused by slow heartbeat and you do not have a permanent pacemaker
• if you have a history of bleeding or clotting problems, stroke, gouty arthritis, or high blood uric acid levels
• if you have received medicine to dissolve a blood clot (eg, alteplase) within 24 hours of taking ticagrelor
• if you take another medicine to prevent or treat blood clots

Dose adjustment of levetiracetam is not necessary in liver impairment.

Specification:

Possible side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if you have any side effects that persist or become bothersome. Seek medical attention right away if any of these SEVERE side effects occur:

1.Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bleeding in the eye; chest pain; fainting; fast, slow, or irregular heartbeat; light-headedness; purple skin patches; shortness of breath; symptoms of stroke (eg, sudden numbness or weakness of an arm, leg, or the face; one-sided weakness; sudden confusion, trouble speaking, or trouble understanding others; loss of balance, coordination, or trouble walking; sudden severe headache or dizziness with no known cause); symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or that get bigger; any bleeding that is severe or that you cannot stop).

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