Oral Chemical Tianeptine Brain Enhancing Supplements CAS 66981-73-5

Oral Chemical Tianeptine Brain Enhancing Supplements CAS 66981-73-5

Introduciton

Tianeptine is a drug used primarily in the treatment of major depression disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricylic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamete receptor activity 

Basic Information

Tianeptine is a research nootropic and one of the only in its class. It acts as a Selective Serotonin Reuptake Enhancer (SSRE). Tianeptine is the only known in the class and has the opposite effects of SSRI’s. Administration of an SSRI and tianeptine are known to cause cancelling effects. Regardless, tianeptine is thought to carry anxiolytic, anti-depressive and some analgesic properties as well as being a nootropic. Tianeptine may enhance dopamine release. It may also have effects on AMPA and NMDA glutamate receptors.

Medical use

• Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitritylibe, imipramine and fluoxetine, but with significantly fewer side effects. It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. 

• Tianeptine has been found to be effective in depression in Parkinson's disease and in post traumatic stress disorder, of which it was as safe and effective as fluoxetine and moclobemide.
• Tianeptine has been reported to be very effective for athsma. In August 1998, Dr. Fuad Lechin and colleagues at the Central University of Venezuela Institute of Experimental Medicine in Caracaspublished the results of a 52-week randomized controlled trial of asthmatic children.

Side Effect

Compared to other TCAs it produces significantly fewer cardiovascular, anticholinegic  (like dry mouth or constipation), sedative and appetite-stimulating effects. A recent review found that it was amongst the antidepressants most prone to causing hepatotoxicity (liver damage), although the evidence to support this concern was of limited quality. Although not well studied with tianeptine, it has been shown for tricyclic antidepressants that they may cause cardiac arrhythmias.

Nootropics series