Pharmaceutical Ingredient Sitagliptin Phosphate Intermediate Chemicals CAS 762240-92-6

Pharmaceutical Ingredient Sitagliptin Phosphate Intermediate Chemicals CAS 762240-92-6

Product Info :

Molecular Formula: C6H7F3N4.HCl
CAS Registry Number: 762240-92-6
Usage: An intermediate of sitagliptin phosphate

About sitagliptin phosphate :

As an orally active agent, Sitagliptin phosphate exhibits a potent inhibitory effect on DPP-4 with IC50 of 19 nM from Caco-2 cell extracts. MK0431 reduces in vitro migration of isolated splenic CD4 T-cells through a pathway involving cAMP/PKA/Rac1 activation. A recent study demonstrates that sitagliptin exerts a novel, direct action in order to stimulate GLP-1 secretion by the intestinal L cell through a DPP-4-independent, protein kinase A- and MEK-ERK1/2-dependent pathway. It therefore reduces the effect of autoimmunity on graft survival.

Packaging:

(1) 10g/100g/500g/1kg, packaged by Aluminum foil bag.
(2) Customized package.

Chemical Properties:

Appearance	white or off white power
Molecular Weight	228.60
Molecular Structure
Density	1.468 g/cm3
Boiling Point	266.2 °C at 760 mmHg
Melting Point	236-246°C
Flash Point	114.8 °C
Storage Temperature	Refrigerator

 
Safety Information:
 

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