Enobosarm MK-2866 Selective Androgen Receptor Modulators CAS 841205-47-8

Enobosarm MK-2866 Selective Androgen Receptor Modulators CAS 841205-47-8

Description:

Enobosarm ((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide) (also known as ostarine, GTx-024, and MK-2866) is an investigational Selective Androgen Receptor Modulator (SARM) from GTX. Inc for treatment of conditions such as muscle wasting and osteoporosis, formerly under development by Merk & Company.

Application:

• Affects both muscle and bone (assist athletes in training and increase physical stamina and fitness)
• Treatment for osteoporosis
• General treatment for andropause
• Reversing muscle sarcopenia in the elderly
• Treatment for cachexia in cancer patients.

Basic Information

Structure:

According to a recent paper authored by GTx, "Readers are cautioned to note that the name ostarine is often mistakenly linked to the chemical structure of [S-4], which is also known as andarine. The chemical structure of ostarine has not been publicly disclosed. While GTx has not formally disclosed the structure of ostarine, the chemical composition of ostarine is revealed in patent databases such the WIPO and discussed by Zhang et al., 2009 in the primary literature.

Various SARM chemotypes exist (aryl propionamides,quinolines, quinolinones, bicyclic hydantoins), though aryl propionamides such as ostarine, andarine/S-4, and S-23 represent some of the most advanced putative therapeutics under investigation. In terms of atom connectivity, enobosarm differs from andarine by cyano substitutions on the phenyl rings as it replaces both the nitro and acetamido moieties.

SARMs

Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands (The name follows the terminology currently used for similar molecules targeting the estrogen receptor, "Selective androgen receptor modulators" such as tamoxifen) They are intended to have the same kind of effects as androgenic drugs like anabolic steriods, but be much more selective in their action, allowing them to be used for many more clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.

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