Sitagliptin Phosphate Pharmaceutical Intermediates CAS 764667-65-4

Sitagliptin Phosphate Pharmaceutical Intermediates CAS 764667-65-4
 
Product Info :
Molecular Formula: C16H12F6N4O2
CAS Registry Number: 764667-65-4
Usage:An intermediate of sitagliptin phosphate .
 
Packaging:
(1) 10g/100g/500g/1kg, packaged by Aluminum foil bag.
(2) Customized package.
 
About sitagliptin phosphate :
As an orally active agent, Sitagliptin phosphate exhibits a potent inhibitory effect on DPP-4 with IC50 of 19 nM from Caco-2 cell extracts. MK0431 reduces in vitro migration of isolated splenic CD4 T-cells through a pathway involving cAMP/PKA/Rac1 activation. A recent study demonstrates that sitagliptin exerts a novel, direct action in order to stimulate GLP-1 secretion by the intestinal L cell through a DPP-4-independent, protein kinase A- and MEK-ERK1/2-dependent pathway. It therefore reduces the effect of autoimmunity on graft survival.
 
Chemical Properties:

Appearance	white or off white power
Molecular Weight	406.28
Molecular Structure
Density	1.607 g/cm3
Boiling Point	513.902 °C at 760 mmHg
Melting Point	82-84°C
Flash Point	513.902 °C at 760 mmHg
Storage Temperature	Refrigerator
Refractive index	1.58 g/cm3

 
 
Safety Information:
 

 
 
 

 
FAQ:
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.
Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service
Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!
Q6: How should I pay?
A: We accept all kinds of payment ways. such as alibaba trade asssurance, T/T, West union, Paypal.
Q7: Do you provide free sample?
A: Yes, we can provide free sample if we have in stock, just need you to cover the delivery cost.