New Anticancer pharmaceutical active ingredients Ibrutinib powder CAS 936563-96-1

New Anticancer API 99% Purity Ibrutinib powder CAS: 936563-96-1

Introduction

Ibrutinib is a targeted therapy. Ibrutinib inhibits the function of Bruton's tyrosine kinase (BTK). (For more detail, see "How this drug works," below.)

What Ibrutinib Is Used For:

• Mantle cell lymphoma (MCL) who have received at least one prior therapy.
• Chronic lymphocytic leukemia (CLL) who have received at least one prior therapy.
• Waldenstrom’s macroglobulinemia

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

Basic information

How Ibrutinib Is Given:

• Ibrutinib is a capsule, taken by mouth once daily. You may take 1-4 capsules at once depending on your prescribed dose.
• Take ibrutinib at approximately the same time each day.
• Take ibrutinib exactly as prescribed.
• Swallow ibrutinib capsules whole with at least 8 ounces of water. Do not crush, open, chew or dissolve capsules.
• Do not change your dose or stop ibrutinib unless your health care provider tells you to.
• If you miss a dose of irbrutinib, it should be taken as soon as possible on the same day with return to the normal schedule the following day. Do not take extra capsules of ibrutinib to make up the next dose.
• Do not take more than 1 dose of ibrutinib at one time. Call your health care provider and go to the emergency room right away if you take too much.
• Store at room temperature (68° F to 77° F); keep medication in original bottle; protect from high humidity, moisture and light.
• Keep out of reach from children and pets.
• Safely throw away any ibrutinib that is out of date or unused (ask your provider for directions on how to discard the medication).
• The amount of ibrutinib that you will receive depends on many factors, including your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact ibrutinib dosage and schedule.

Ibrutinib Side Effects:

• Important things to remember about the side effects of ibrutinib:
• Most people will not experience all of the ibrutinib side effects listed.
• Ibrutinib side effects are often predictable in terms of their onset, duration, and severity.
• Ibrutinib side effects are almost always reversible and will go away after therapy is complete.
• Ibrutinib side effects may be quite manageable. There are many options to minimize or prevent the side effects of ibrutinib.

The following side effects are common (occurring in greater than 30%) for patients taking ibrutinib:

• Decreased platelets
• Diarrhea
• Decreased neutrophils
• Decreased hemaglobin
• Fatigue
• Musculoskeletal pain
• Swelling
• Upper respiratory tract infection
• Nausea
• Bruising

These are less common side effects (occurring in 10-29%) for patients receiving ibrutinib:

• Shortness of breath
• Constipation
• Rash
• Abdominal pain
• Vomiting
• Decreased appetite
• Cough
• Fever
• Stomatitis
• Dizziness
• Urinary Tract Infection
• Pneumonia
• Skin infections
• Asthenia
• Muscle spasms
• Sinusitis
• Headache
• Dehydration
• Dyspepsia
• Petechiae
• Arthralgia
• Nosebleeds