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|Appearance:||Yellow Solid||Synonyms:||TIMTEC-BB SBB000930;7,8-DIHYDROXYFLAVONE;7,8-Dihydroxyf|
7,8-DIHYDROXYFLAVONE Yellow powder TIMTEC-BB SBB000930 Lowering blood pressure
7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-moleculeagonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor(BDNF).7,8-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier.
7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheim er's disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD.
|Synonyms:||TIMTEC-BB SBB000930;7,8-DIHYDROXYFLAVONE;7,8-Dihydroxyflavone hydrate|
|Product Categories:||Di-substituted Flavones;Biochemistry;Flavonoids;Inhibitors|
|storage temp.||Store at +4°C|
|CAS DataBase Reference||38183-03-8(CAS DataBase Reference)|
|Chemical Properties||Yellow Solid|
|Biological Activity||Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (K d = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo .|
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