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35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine

Good quality Pharmaceutical Intermediates for sales
Good quality Pharmaceutical Intermediates for sales
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35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine

China 35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine supplier
35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine supplier 35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine supplier

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Product Details:

Place of Origin: China
Brand Name: VANZ
Certification: ISO9001
Model Number: Triciribine

Payment & Shipping Terms:

Minimum Order Quantity: 1G
Price: USD
Packaging Details: Aluminum foil bags or drum
Delivery Time: 3-5 Working days
Payment Terms: T/T, Western Union, MoneyGram
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Detailed Product Description
Name: Triciribine CAS: 35943-35-2
Appearance: White Powder Purity: 99%
Test Method: HPLC Formula: C13H16N6O4

35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine

Introduction

  • Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase.
  • Triciribine exhibits maximum growth inhibition around 1-10 μM and inhibits phosphorylation of Akt, as well as downstream p70S6K, to basal levels at 100μM (IC50 = 130 nM).
  • Triciribine shows particular promise for inhibiting growth in Nf1 and Trp53 mutant astrocytoma cells in a grade-dependent manner. The WHO II K1861-10 line is inhibited, incompletely (69% maximum inhibition), with a GI50 value of 1.7 μM for Triciribine, whereas higher-grade tumor lines (KR158, KR130, and SF295) are inhibited to a greater extent (>80% maximum inhibition) at lower GI50 values (0.4–1.1 mM).
  • Importantly, Triciribine is much less effective at inhibiting primary astrocytes (GI5013.6 mM), suggesting that this inhibitor may show specificity for tumor cells. Triciribine inihibits HIV-1with an IC50 of 20 nM. Greater than 90% inhibition is achieved at 0.1μM and complete inhibition of syncytia formation is achieved at 5μM.

Basic Information 

 

Chemical name Triciribine /API-2
CAS NO. 35943-35-2
Synonym API-2;nosyl-;3-amine;hthylene;uranosyl-;NSC 154020;TRICIRIBINE;AKT INHIBITOR V;API-2 (Tricirbine)
Molecular Formula C13H16N6O4
Molecular Weight 320.3
Store at Normal ROOM
Purity 99%
Appearance white powder
Flash point 388.3°C
Boiling point 718.5°C at 760 mmHg
Density 2.02g/cm3

 

 

  • Associated cell toxicity in the same cell line for Triciribine is 46 μM, resulting in selectivity indices of 2250. Triciribine markedly inhibits HIV-1-induced p24 core antigen production, reverse transcriptase, and infectious virus production in a dose-dependent manner using HIV-1 acutedly infected CEM-SS, H9, and persistently infected H9III B and U1 cells.Triciribine inhibits Akt phosphorylation at Thr308 and Ser473 and Akt activity in the human prostate cancer cell line PC-3.
  • Triciribine sensitizes PC-3 cells to TRAIL- and anti-CD95-induced apoptosis, whereas the cells remain resistant to DNA damaging chemotherapeutics.Triciribine is highly selective for Akt and does not inhibit the activation of phosphatidylinositol 3_-kinase, phosphoinositide-dependent kinase-1, protein kinase C, serum and glucocorticoid-inducible kinase, protein kinase A, signal transducer and activators of transcription 3, extracellular signal-regulated kinase-1/2, or c-Jun NH2-terminal kinase.

 

Shipping item:

 

1. CIP by courier to your door(UPS, FedEx, DHL, EMS,TNT,HONGKONG POST).

2. CIF BY SEA OR AIR in bulk quantity.

Delivery time: Within 3 days after receive payment.

 

 35943-35-2 Active Pharmaceuticals Ingredients Antineoplastic Triciribine

 

Warm welcome to visit my factory indeed.

 

Our company is a direct manufacturer of APIs, pharmaceutical intermediates and fine chemicals. We 've developed a series of APIs ranging in various indications such as respiratory system, anti neoplastic, anti diabetes and anti depressant, etc. We also provide custom synthesis service of novel APIs and pharmaceutical intermediates.

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