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|CAS:||154361-50-9||Appearance:||White Appearance Powder|
|Formula:||C15H22FN3O6||Molar Mass:||359.35 G/mol|
Anticancer API Apecitabine Active Pharmaceutical Ingredient CAS 154361-50-9
Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of numerous cancers. Capecitabine is a prodrug that is enzymatically converted to 5-fluorouracil(5-FU) in the body.
It is on the World Health Organization`s List of Essential Medicines, a list of the most important medications needed in a basic health systom.
It`s used in the treatment of the following cancers:
It is often referred to as Xeloda, the name under which it is marketed by Genentech. It is available in 500-mg and 150-mg tablets.
|Appearance||white crystal powder|
Very common (>10% frequency)
The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes capecitabine, 5-fluorouracil and tegafur. Genetic variations within the DPD gene (DPYD) can lead to reduced or absent DPD activity, and individuals who are heterozygous or homozygous for these variations may have partial or complete DPD deficiency; an estimated 0.2% of individuals have complete DPD deficiency.
History of hypersensitivity to fluorouacil, capecitabine or any of its excipients
DPD deficiency (see Pharmacogenetics)
Pregnancy and lactation
Severe leucopenia, neutropenia, or thrombocytopenia
Severe hepatic impairment or severe renal impairment
Treatment with sorivudine or its chemically related analogues, such as brivudine
Drugs it is known to interact with include:
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