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Anticancer API Apecitabine Active Pharmaceutical Ingredient CAS 154361-50-9

Good quality Pharmaceutical Intermediates for sales
Good quality Pharmaceutical Intermediates for sales
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Anticancer API Apecitabine Active Pharmaceutical Ingredient CAS 154361-50-9

China Anticancer API Apecitabine Active Pharmaceutical Ingredient CAS 154361-50-9 supplier
Anticancer API Apecitabine Active Pharmaceutical Ingredient CAS 154361-50-9 supplier Anticancer API Apecitabine Active Pharmaceutical Ingredient CAS 154361-50-9 supplier

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Product Details:

Place of Origin: China
Brand Name: VANZ
Certification: ISO9001
Model Number: 154361-50-9

Payment & Shipping Terms:

Minimum Order Quantity: 10g. Sample available
Packaging Details: Aluminum foil bags
Delivery Time: 3-5 days
Payment Terms: T/T, Western Union, MoneyGram
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Detailed Product Description
CAS: 154361-50-9 Appearance: White Appearance Powder
Assay: 99%min COA: Available
Formula: C15H22FN3O6 Molar Mass: 359.35 G/mol

Anticancer API Apecitabine Active Pharmaceutical Ingredient CAS 154361-50-9

 

Introduction

 

Capecitabine  is an orally-administered chemotherapeutic agent used in the treatment of numerous cancers. Capecitabine is a prodrug  that is enzymatically converted to 5-fluorouracil(5-FU) in the body.

It is on the World Health Organization`s List of Essential Medicines, a list of the most important medications needed in a basic health systom.

 

Medical Uses

 

It`s used in the treatment of the following cancers:

  1. Colorectal cancer(either as neoadjuvant therapy with radiation, adjuvant therapy or for metastatic cases)
  2. Breast cancer(metastatic or as monotherapy/ combotherapy; this is licensed as a second-line treatment in the UK)
  3. Gastric cancer (off-label in the US; this is a licensed in the UK)
  4. Oesophageal cancer(off-lable in the US)

It is often referred to as Xeloda, the name under which it is marketed by Genentech. It is available in 500-mg and 150-mg tablets.

 

Name Capecitabine
CAS 141977-79-9
Synomyms Pentyl [1-(3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1H-pyrimidin-4-yl]carbamate
Appearance white crystal powder
Sample Available

 

Adverse effects 

 

Very common (>10% frequency)

  • Appetite loss
  • Diarrhea
  • Vomiting
  • Nausea
  • Stomatitis
  • Abdominal pain
  • Fatigue
  • Weakness
  • Hand-foot syndrone
  • Oedema
  • Fever
  • Pain
  • Headache
  • Hair loss
  • Dermatitis
  • Indigestion
  • Shortness of breath
  • Eye irritation
  • Myelosuppression

Pharmacogenetics

The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes capecitabine, 5-fluorouracil and tegafur. Genetic variations within the DPD gene (DPYD) can lead to reduced or absent DPD activity, and individuals who are heterozygous or homozygous for these variations may have partial or complete DPD deficiency; an estimated 0.2% of individuals have complete DPD deficiency.

 

Contraindications


Contraindications include:

History of hypersensitivity to fluorouacil, capecitabine or any of its excipients
DPD deficiency (see Pharmacogenetics)
Pregnancy and lactation
Severe leucopenia, neutropenia, or thrombocytopenia
Severe hepatic impairment or severe renal impairment
Treatment with sorivudine or its chemically related analogues, such as brivudine

 

Drug interactions


Drugs it is known to interact with include:

  • Sorivudine or its analogues, such as, brivudine.
  • Allopurinol as it decreases the efficacy of 5-FU.
  • CYP2C9 substrates, including, warfarin and other coumarin-derivatives anticoagulants
  • Phenytoin, as it increases the plasma concentrations of phenytoin.
  • Calcium folinate may enhance the therapeutic effects of capecitabine by means of synergising with its metabolite, 5-FU. It may also induce more severe diarrhoea by means of this synergy.

Anticancer API Apecitabine Active Pharmaceutical Ingredient CAS 154361-50-9

 

FAQ

  • Q1: Are you a manufacturer ?

         A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small            quantity and customer synthesis products in our lab located in Wuhan. But we also do some                 trading business.

  • Q2: What`s your delivery

        A: We send goods in 3 working day after receiving your payment by DHL, FEDEX, TNT, EMS, AIR         OR SEA as you request, usually you can find shipping details in 3 to 5 working days after your             payment.

  • Q3: What certificates and documents do you offer?

         A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

  • Q4: Why should I choose you?

         A: Factory supply with the most compatitive price and high quality!!!

 

Contact Details
Wuhan Vanz Pharm Inc.

Contact Person: Amy

Tel: +8613277095342

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