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|Bioavailability:||Oral||Biological Half-life:||Variable (about 24 Hours)|
|Synonyms:||Cyclosporine, Cyclosporin, Ciclosporin A,cyclosporine A, Cyclosporin A(CsA)||COA:||Available|
HPLC Ciclosporin Api Intermediates Immunosuppressant Drug CAS 59865-13-3
Specification:CP, EP, USP
Packing: 25kg/drum or customized requirement
Usage: An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Ciclosporin, also spelled cyclosporine, is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity and growth of T cells.
It was initially isolated from the fungus Tolypocladium inflatum found in a soil samples in 1969 from Norway, by Hans Peter Frey. Most ptptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which is rarely encountered in nature.
Ciclosporin was discovered in 1976. It is on the WHO Model List of Essential Medicine, the most important medications needed in a basic health system.
Certificate of Analysis
|Product: CYCLOSPORINE(USP36)||Batch No:FM20160618|
|Quantity: 50kg||Report Date:June.26,2016|
|RESULTS OF EXAMINATION|
|Appearance||White crystalline powder||White crystalline powder|
|Loss on dying||2.0%max||0.6%|
|2 sum of all impurity||1.5%max||1.1%|
|Any other impurity||0.1%max||0.07%|
|CONCLUSION: Product complies with USP36 Standard.|
Ciclosporin is approved by the FDA to prevent and treat graft-versus-host disease in bone-marrow transplantation and to prevent rejection of kidney, heart, and liver transplants.It is also approved in the US for the treatment of rheumatoid arthritis and psoriasis, as an ophthalmic emulsion for the treatment of dry eyes (a common symptom of Sjögren's syndrome), and as a treatment for persistent nummular keratitis following adenoviral keratoconjunctivitis.