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| CAS: | 93479-97-1 | Appearance: | White Powder |
|---|---|---|---|
| Grade: | Medicine Grade | Assay: | 99%min HPLC |
| Other Names: | 3-Ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide | Formula: | C24H34N4O5S |
| High Light: | active pharmaceuticals ingredients,active pharma ingredients |
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Antidiabetic Glimepiride Active Pharmaceutical Ingredient CAS 93479-97-1
Introduction
Basic Information
| Name | Glimepiride |
| Synonyms |
1h-pyrrole-1-carboxamide,2,5-dihydro-3-ethyl-4-methyl-n-(2-4(((((4-methylcyc glimepirid Glimepirid, hoe4990, trans-lohexyl)amino) carbony)sulfonyl)ohenyl)ethyl)-2-oxo |
| CAS | 93479-97-1 |
| Formula | C24H34N4O5S |
| Molar mass | 490.617g/mol |
Empirical Formula: C24H34N4O5S
Molecular Weight: 490.6156
Index of Refraction: 1.599
Molar Refractivity: 129.42 cm3
Molar Volume: 378.8 cm3
Surface Tension: 58.2 dyne/cm
Density: 1.29 g/cm3
Melting point: 212.2-214.5 °C
Storage tempreture: Room temp
Solubility: DMSO: >10 mg/mL
Sensitive: Moisture sensitive
Appearance: White cyrstalline solid
Structure of Glimepiride (CAS NO.93479-97-1):
Side Effects
Side effects from taking glimepiride include gastrointestinal tract(GI), disturbances, occasional allergic reactions, and rarely blood production disorders including thrombocytopenia, leukopenia, and hemolytic anemia. In the initial weeks of treatment, the risk of hypoglycemia may be increased. Alcohol consumption and exposure to sunlight should be restricted because they can worsen side effects.
Mechanism of action
Like all sulfonylureas, glimepiride acts as an insulin secretagogue It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors.
Not all secondary sufonylureas have the same risks of hypoglycemia. Glibenclamide (glyburide) is associated with an incidence of hypoglycemia of up to 20–30%, compared to as low as 2% to 4% with glimepiride. Glibenclamide also interferes with the normal homeostatic suppression of insulin secretion in reaction to hypoglycemia, whereas glimepiride does not. Also, glibenclamide diminishes glucagon secretion in reaction to hypoglycemia, whereas glimepiride does not.
IUPAC Name: 4-Ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl] ethyl]-5-oxo-2H-pyrrole-1-carboxamide
FAQ
Q1: Are you a manufacturer ?
A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan. But we also do some trading business.
Q2: What`s your delivery
A: We send goods in 3 working day after receiving your payment by DHL, FEDEX, TNT, EMS, AIR OR SEA as you request, usually you can find shipping details in 3 to 5 working days after your payment.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
Contact Person: Amy
Tel: +8613277095342
