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Antidiabetic Glimepiride Active Pharmaceutical Ingredient CAS 93479-97-1

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Antidiabetic Glimepiride Active Pharmaceutical Ingredient CAS 93479-97-1

China Antidiabetic Glimepiride Active Pharmaceutical Ingredient CAS 93479-97-1 supplier
Antidiabetic Glimepiride Active Pharmaceutical Ingredient CAS 93479-97-1 supplier Antidiabetic Glimepiride Active Pharmaceutical Ingredient CAS 93479-97-1 supplier

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Product Details:

Place of Origin: China
Brand Name: VANZ
Certification: ISO9001
Model Number: 93479-97-1

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Packaging Details: 1kg aluminum foil bag, 25 kg drum
Delivery Time: 3-5 working days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500KG Per Month
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Detailed Product Description
CAS: 93479-97-1 Appearance: White Powder
Grade: Medicine Grade Assay: 99%min HPLC
Other Names: 3-Ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide Formula: C24H34N4O5S

Antidiabetic Glimepiride Active Pharmaceutical Ingredient CAS 93479-97-1

 

Introduction

  • Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylureaantidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea,or as second-generation.
  • Glimepiride is indicated to treat type 2 diabetes mellitus; its mode of action is to increase insulin production by the pancreas. It is not used for type 1 diabetes  because in type 1 diabetes the pancreas is not able to produce insulin.

Basic Information

 

Name Glimepiride
Synonyms

1h-pyrrole-1-carboxamide,2,5-dihydro-3-ethyl-4-methyl-n-(2-4(((((4-methylcyc glimepirid

Glimepirid, hoe4990, trans-lohexyl)amino) carbony)sulfonyl)ohenyl)ethyl)-2-oxo 

CAS 93479-97-1
Formula C24H34N4O5S
Molar mass 490.617g/mol

 

Empirical Formula: C24H34N4O5S
Molecular Weight: 490.6156
Index of Refraction: 1.599
Molar Refractivity: 129.42 cm3
Molar Volume: 378.8 cm3
Surface Tension: 58.2 dyne/cm
Density: 1.29 g/cm3
Melting point: 212.2-214.5 °C
Storage tempreture: Room temp
Solubility: DMSO: >10 mg/mL
Sensitive: Moisture sensitive
Appearance: White cyrstalline solid
Structure of Glimepiride (CAS NO.93479-97-1):
 

Side Effects

 

Side effects from taking glimepiride include gastrointestinal tract(GI), disturbances, occasional allergic reactions, and rarely blood production disorders including thrombocytopenia, leukopenia, and hemolytic anemia. In the initial weeks of treatment, the risk of hypoglycemia may be increased. Alcohol consumption and exposure to sunlight should be restricted because they can worsen side effects.

 

Mechanism of action

 

Like all sulfonylureas, glimepiride acts as an insulin secretagogue It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors.

Not all secondary sufonylureas have the same risks of hypoglycemia. Glibenclamide (glyburide) is associated with an incidence of hypoglycemia of up to 20–30%, compared to as low as 2% to 4% with glimepiride. Glibenclamide also interferes with the normal homeostatic suppression of insulin secretion in reaction to hypoglycemia, whereas glimepiride does not. Also, glibenclamide diminishes glucagon secretion in reaction to hypoglycemia, whereas glimepiride does not.

 

 

Antidiabetic Glimepiride Active Pharmaceutical Ingredient CAS 93479-97-1
IUPAC Name: 4-Ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl] ethyl]-5-oxo-2H-pyrrole-1-carboxamide
 

FAQ

 

Q1: Are you a manufacturer ?
A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan. But we also do some trading business.
Q2: What`s your delivery
A: We send goods in 3 working day after receiving your payment by DHL, FEDEX, TNT, EMS, AIR OR SEA as you request, usually you can find shipping details in 3 to 5 working days after your payment.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

Contact Details
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Contact Person: Amy

Tel: +8613277095342

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