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|Name:||7,8-Dihydroxyflavone Hydrobromide||Other Names:||4'-Dimethylamino 7,8-Dihydroxyflavone; 4'-DMA-7,8-DHF|
|Molecular Weight:||378.217||Appearance:||Yellow Powder|
7 8 Dihydroxyflavone Hydrobromide Drug API Intermediate CAS 1205548-00-0
7,8-Dihydroxyflavone is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It acts as a potent and selective small-molecule agonist of the TrkB receptor, the main signaling receptor of brain-derived neurotrophic factor. 7,8-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier.
|Other names||4'-Dimethylamino 7,8-Dihydroxyflavone; 4'-DMA-7,8-DHF|
7,8-DHF has remarkable therapeutic efficacy in a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome; age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents. Also, it possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity. It also blocks methamphetamine-induced dopaminergic neurotoxicity.
7,8-DHF can act as a weak aromatase inhibitor in vitro. In addition, it can inhibit aldehyde dehydrogenase and estrogen sulfotransferase in vitro.
A variety of close structural analogs of 7,8-DHF also act as TrkB agonists in vitro, including diosmetin (5,7,3'-trihydroxy-4'-methoxyflavone), norwogonin (5,7,8-trihydroxyflavone), 4'-dimethylamino-7,8-dihydroxyflavone, 7,8,3'-trihydroxyflavone, 7,3'-dihydroxyflavone, 7,8,2'-trihydroxyflavone, 3,7,8,2'-tetrahydroxyflavone, and 3,7-dihydroxyflavone.
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Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
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A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.
Strict quality control-comes form our sophisticated management system.
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Q7: Do you provide free sample?
A: Yes, we can provide free sample if we have in stock, just need you to cover the delivery cost.