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|Appearance:||White Cystalline Powder||Purity:||99%|
|Melting Point:||137-141°C||CAS NO.:||105816-04-4|
Nateglinide Pharmaceutical Raw Materials Epalrestat Cas 82159-09-9
CAS Registry Number:105816-04-4
Nateglinide [INN]; Fastic; trans-N-((4-(1-Methylethyl)cyclohexyl)carbonyl)-D-phenylalanine; A 4166; Starlix; Nateglinide(105816-04-4 ); Nateglinide,105816-04-4; Starsis (TN); (2R)-3-phenyl-2-[[(1S,3S)-3-propan-2-ylcyclohexanecarbonyl]amino]propanoic acid; D-Phenylalanine,N-[[trans-4-(1-methylethyl)- cyclohexyl]carbonyl]-; Starsis; (-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine; Nateglynide; Nateglinide intermediate; Nateglinide-H; AY 4166; D-Phenylalanine, N-((4-(1-methylethyl)cyclohexyl)carbonyl)-, trans-;
Epalrestat is an aldose reductase inhibitor.
"Long-term treatment with epalrestat is well tolerated and can effectively delay the progression of diabetic neuropathy and ameliorate the associated symptoms of the disease, particularly in subjects with good glycemic control and limited microangiopathy."
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scientific research reagents, which are widely used in molecular biology, pharmacology research aspects.According to palmer division, he is a kind of reversibility of aldose reductase non-competitive inhibitors, selective inhibition of aldose reductase.Clinical studies have shown that, in accordance with the company he can inhibit in patients with diabetic peripheral neuropathy of the accumulation of sorbitol in red blood cells, compared with the control group can improve the patient's subjective symptom and nerve dysfunction.Animal experiments showed that according to palmer company he can significantly inhibit the diabetes mellitus model of rat sciatic nerve, the accumulation of sorbitol in red blood cells and retina, improve the motor nerve conduction velocity and autonomic nerve function;On neural morphology, according to Mr He can improve axon abnormal flow, increase the density of myelinated nerve fibers in the sciatic nerve and sural nerve myelin sheath thickness, axon area, axon cylindrical rate;In addition, according to Mr He also can improve the model animal blood flow to the sciatic nerve and inositol makes it more expensive.
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