HPLC 99 Rosuvastatin Intermediates Cas 287714-41-4 Pharmaceutical Intermediates
Product Info :
745.6 °C at 760 mmHg
About Rosuvastatin :
1. Hypolipidemic effect
Rovastatin significantly reduced blood lipid, general statin to reduce low-density lipoprotein cholesterol (LDL-C) level of 17% to 54%. The results of the phase Ⅱ clinical trial of rosuvastatin showed that LDL-C was reduced to 65% at the dose of 80 mg, which is the best effect of statins. Rovastatin may increase the number of LDL receptors. In human hepatoma, rosuvastatin increased the amount of LDL receptor mRNA about 10 times more than pravastatin.
2. Selective effects on liver cells
Hepatocyte-derived cholesterol is the main cause of the formation of blood cholesterol, and cholesterol derived from non-hepatocytes is essential for normal cells. The main site of action of lovastatin is the liver, from the inhibition of sterol synthesis, the drug on the rat liver selectivity than the peripheral tissue selectivity, and than pravastatin or simvastatin on liver tissue selection Sex should be high. Through the active absorption process, rosuvastatin is absorbed into the liver cells, which in liver cells in the inhibition of cholesterol than 1000 times higher in fibroblasts.
3. anti-atherosclerotic effect
Rovastatin can reduce blood lipids, reduce lipid infiltration and foam cell formation, delayed atherosclerosis beneficial; the drug can also block the hydroxymethyl glutaric acid pathway, in particular the inhibition of isoprenoid metabolites Formation and inhibition of smooth muscle cell proliferation and promote apoptosis and stabilize atherosclerotic plaques, delay the occurrence of atherosclerosis, development.
(1) 10g/100g/500g/1kg, packaged by Aluminum foil bag.
(2) Customized package.
||Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.
Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service
Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!
Q6: How should I pay?
A: We accept all kinds of payment ways. such as alibaba trade asssurance, T/T, West union, Paypal.
Q7: Do you provide free sample?
A: Yes, we can provide free sample if we have in stock, just need you to cover the delivery cost.