Pharma Raw Materials Ticagrelor Intermediates Powder CAS 145783-14-8

Product Info :

Molecular Formula: C7H7Cl2N3O2S
CAS Registry Number: 145783-14-8
Usage:An intermediate of Ticagrelor .

About Ticagrelor :

Ticagrelor is a new kind of antiplatelet aggregation drug. It was successfully researched and developed by the United States company - AstraZeneca, and is the world's first reversible type combined with oral P2Y12 ADP receptor antagonist, the drug has reversible effect on vascular smooth muscle cells (VSMC) on purinoceptor 2, P2, don't need metabolic activation, has obvious inhibitory effect on platelet aggregation caused by adenosine diphosphate (ADP), working quickly after been taken by oral, and can effectively improve symptoms of patients with acute coronary heart disease (CHD). Unlike thiophene and pyridine drugs, ticagrelor is reversible inhibitor for P2Y12 receptor, so it is particularly applicable for those patients that should be carried out in the early anticoagulation therapy after surgery.
Astrazeneca's started developing Ticagrelor since 1999, the European heart association (ESC)firstly released Ⅲ period test results in 2009, which detailed compared the effects on patients with acute coronary syndrome (ACS).
In November 2009, Astrazeneca submitted new drug applications for Ticagrelor to the European Union and the United States, respectively.
Ticagrelor was approved used in adult patients with acute coronary syndrome (ACS) thrombosis incident prevention of atherosclerosis by the European Union in December 2010.
On December 17, 2010, the United States food and drug administration (FDA) has again decided to postpone approval of astrazeneca's new antiplatelet drugs for ticagrelor, and FDA lettered to require the company to provide additional analysis about the research on platelet inhibition and the prognosis of patients.
So far, ticagrelor has been approved for sale in 41 countries, and included in the seven countries, such as the UK medical compensation scope.
 
Packaging:

(1) 10g/100g/500g/1kg, packaged by Aluminum foil bag.
(2) Customized package.

Chemical Properties:

Appearance	Off white powder
Molecular Weight	266.96
Molecular Structure

 
Safety Information:

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