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selective androgen receptor modulators sarms
YK11 Selective Androgen Receptor Modulators SARMs CAS 1370003-76-2
S.A.R.M. “YK-11” is one of the most powerful S.A.R.M.S (Selective Androgen Receptor Modulator) on the market today. It is used to achieve Anabolic Steroid type results, but without the negative side effects and legality issues.
Gain Lean Muscle Tissue
Lose Fat simultaneously.
Taking a Moderate dose (4mg – 8mg per day, 2 to 4 capsules per day) of “YK-11” the user can expect to get a more Aesthetic Physique (Lean, Hard and Strong).
Taking a Large dose (18mg – 22mg per day, 9 to 11 capsules) of “YK-11” the user will experience Gaining More Muscle Tissue and maintaining Extreme Muscle Fullness (The “Pumped” Look) 24/7.
This is attributed to the abilities of “YK-11” inducing the muscle cells to produce more Follistatin (even more than DHT Steroids), which helps inhibit the production of Myostatin (Myostatin – limits muscle growth). This S.A.R.M. has the potential for being as good as Testosterone in term of Muscle Strengthening, but without the negative side effects.
Initial Research by Japanese Researcher, Yuichiro Kanno, in 2011 at Toho University, has shown that “YK-11” attaches itself to the androgen receptor and makes muscle cells produce more anabolic factors. He also discovered that “YK-11” induces the muscle cells to produce more Follistatin, which decreases Myostatin and increases Muscle Growth.
How YK11 Works
YK11 attaches itself to the AR (androgen receptor), but only inducts methods that lead to the traditional side effects of androgens such as growth of body hair and prostate and enhanced aggression – to a restricted degree.
Most SARMS have quite limited androgenic side effects, but frequently only quite few anabolic effects when likened to testosterone. But, this doesn’t occur for YK11 as reported in Biological and Pharmaceutical Bulletin in 2013.
Kanno tested C2C12 muscle cells and not lab animals or humans. It has been discovered that muscle cells produce more anabolic factors if exposed to 500 nmol (nanomoles) YK11 than if you expose the same muscle cells to 500 nmol DHT.
YK11 induces muscle cells to make more follistatin (more than DHT does) – a strong myostatin inhibitor. YK11 works through the androgen receptor.
With that said, YK11 can be as good as testosterone in terms of muscle strengthening, but minus the detrimental side effects.
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SARMS Chemical Composition
SARMS or Selective Androgen Receptor Modulators contain androgens. Androgens are a special kind of hormones that act as ligands (a molecule linked to another molecule) that connect to cellular androgen receptors (AR). The AR is integrated in a composite signal transduction conduit that ultimately leads to bigger expression of particular genes. This connection to the AR is what makes all prohormones and steroids give their muscle growth properties.
Selective receptor modulator is a drug that can both obstruct or fuel similar nuclear hormone receptor in different conditions. If it can obstruct or fuel a receptor in a tissue selective mode, it has the ability to replicate the important effects in one tissue and concurrently reduce the adverse effects of the natural or synthetic steroidal hormones in other tissues.
Unlike testosterone cypionate, SARMS is more than 200 times more powerful in muscle stimulation and 80 times more selective for muscle.
SARMS is believed to have the capacity to employ the benefits of anabolic supplements while reducing the side effects of steroids.
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