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White Powder 99% USP Grade Active Pharmaceutical Ingredient Estradiol Oestradiol CAS 50-28-2

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White Powder 99% USP Grade Active Pharmaceutical Ingredient Estradiol Oestradiol CAS 50-28-2

White Powder 99% USP Grade Active Pharmaceutical Ingredient Estradiol Oestradiol CAS 50-28-2
White Powder 99% USP Grade Active Pharmaceutical Ingredient Estradiol Oestradiol CAS 50-28-2 White Powder 99% USP Grade Active Pharmaceutical Ingredient Estradiol Oestradiol CAS 50-28-2

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Product Details:

Place of Origin: China
Brand Name: VANZ
Model Number: 50-28-2

Payment & Shipping Terms:

Minimum Order Quantity: 100g
Price: 1-10 USD per gram
Packaging Details: 10g,100g, 1kg alunimum foil bags or 25kg drum
Detailed Product Description
Appearance: White Powder Synonyms: Estra-1,3,5(10)-triene-3,17β-diol; 17β-Estradiol
CAS: 50-28-2 Purity: 99%min
MF: C18H24O2 MW: 272.38
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active pharma ingredients

White Powder 99% USP Grade Estradiol Oestradiol API CAS: 50-28-2

 

Estradiol (E2), also spelled oestradiol, is a steroid, an estrogen, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues such as the breasts, uterus, and vagina during puberty, adulthood, and pregnancy, but it also has important effects in many other tissues including bone, fat, skin, liver, and the brain. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species

 

Basic information

 

Name Estradiol
CAS 50-28-2
Appearance  white powder
MF C18H24O2
MW 272.38
Purity 99%min

 

 

Function

  1. Sexual development

  2. Female reproduction

  3. Male reproduction

  4. Bone

  5. Brain

  6. Gynecological cancers

 

Certificate of Analysis
       
Product Name Estradiol Batch Size 10KG
Manufacturing Date 2016.09.08 Batch No. 20160908
Expiry Date 2018.09.07 Report Date 2016.09.08
Reference Standard USP 36 Packing  
TEST ACCEPTANCE CRITERIONS   RESULTS
Identification Infrared Absorption   Positive
Characteristics White or creamy white, crystalline powder   conform
Melting point 173 ~ 179℃   177~ 179℃
Specific rotation ﹢76°~﹢83°   ﹢78.5°
Water ≤3.5%   pass
Assay 97 .0~ 103.0%   99.07%
Loss on drying ≤0.5%   0.16%
Related substances total impurities ≤1.0% Pass
Residual solvents ethanol ≤0.5%   Pass
Particle size     Pass
Conclusion This batch complies with USP 326
Supervisor   Analyst  

Biological activity


Estradiol acts primarily as an agonist of the estrogen receptor (ER), a nuclear steroid hormone receptor. There are two subtypes of the ER, ERα and ERβ, and estradiol potently binds to and activates both of these receptors. The result of ER activation is a modulation of gene transcription and expression in ER-expressing cells, which is the predominant mechanism by which estradiol mediates its biological effects in the body.

Estradiol also acts as an agonist of membrane estrogen receptors (mERs), such as GPER (GPR30), a recently discovered non-nuclear receptor for estradiol, via which it can mediate a variety of rapid, non-genomic effects.Unlike the case of the ER, GPER appears to be selective for estradiol, and shows very low affinities for other endogenous estrogens, such as estrone and estriol.Additional mERs besides GPER include ER-X, ERx, and Gq-mER.

 

In the E2 classical pathway or estrogen classical pathway, estradiol enters the cytoplasm, where it causes dissociation of heat-shock protein (HSP). Estradiol then binds to HSP and can homodimerise (form structures of two HSP and two estradiol molecules) and then bind to specific domains on the nucleus (estrogen response element, ERE), allowing for gene transcription which can take place over hours and days.

 

Estradiol is about 10 times as potent as estrone and about 80 times as potent as estriol in its estrogenic effect.

 

White Powder 99% USP Grade Active Pharmaceutical Ingredient Estradiol Oestradiol CAS 50-28-2 0

 

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