Hubei Vanz Pharm Co.,ltd.

 

warrantable quality,trustable service!

Home
Products
About Us
Factory Tour
Quality Control
Contact Us
Request A Quote
News
Home ProductsActive Pharmaceutical Ingredient

USP Grade 99% HPLC Estriol Active Pharmaceutical Ingredient CAS 50-27-1

I'm Online Chat Now
China Hubei Vanz Pharm Co.,ltd certification
China Hubei Vanz Pharm Co.,ltd certification
I am very happy to cooperate with your company for nearly three years, thank you very attentive service, thank you for the excellent product quality.

—— Stephnie

You always have very fast delivery, very happy to cooperate with you. Thank you.

—— John

Very pleased to become your customer, and very happy for our cooperation, hope to be your long-term parter.

—— Sara

we received the package, very fast, the quality is very good, will continue to buy your products.

—— Luice

I have emailed you a couple times and they get returned as undeliverable. Yes. I am happy with the powders. thank you.

—— Bryan

USP Grade 99% HPLC Estriol Active Pharmaceutical Ingredient CAS 50-27-1

USP Grade 99% HPLC Estriol Active Pharmaceutical Ingredient CAS 50-27-1
USP Grade 99% HPLC Estriol Active Pharmaceutical Ingredient CAS 50-27-1 USP Grade 99% HPLC Estriol Active Pharmaceutical Ingredient CAS 50-27-1

Large Image :  USP Grade 99% HPLC Estriol Active Pharmaceutical Ingredient CAS 50-27-1 Get Best Price

Product Details:

Place of Origin: China
Brand Name: VANZ
Model Number: 50-27-1

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: 3-10 USD per gram
Packaging Details: 10g,100g, 1kg alunimum foil bags or 25kg drum
Detailed Product Description
Appearance: White Powder Synonyms: 16α-Hydroxyestradiol; Estra-1,3,5(10)-triene-3,16α,17β-triol
CAS: 50-27-1 Purity: 99%min
MF: C18H24O3 MW: 288.38
High Light:

active pharmaceuticals ingredients

,

active pharma ingredients

USP Grade Estriol Active Pharmaceutical Ingredient CAS: 50-27-1

 

Estriol (E3), or oestriol, also known as 16α-hydroxyestradiol or as estra-1,3,5(10)-triene-3,16α,17β-triol, is a natural steroidal estrogen  and one of the three main estrogens in the human body.Production of estriol by the ovaries  is almost undetectable in non-pregnant women. However, during pregnancy, estriol is synthesized in very high amounts by the placenta and is by far the most produced estrogen in the body,although circulating levels are similar to those of other estrogens due to a relatively high rate of metabolism and excretion.

 

Basic information

 

Name Estriol
CAS 50-27-1
Appearance  white powder
MF C18H24O3
MW 288.38
Purity 99%min

 

 

Function

  1. Estriol Reduces Markers of Cardiovascular Risk

  2. Estriol Improves Bone Mineral Status in Women With Osteoporosis

  3. Estriol Reduces Brain Lesions of Multiple Sclerosis

  4. Estriol Protects Urinary Health in Postmenopausal Women

Mechanism of action

ER agonist

Similarly to estradiol and estrone, estriol binds to and acts as an agonist of both of the estrogen receptors (ER),  ERα and ERβ The affinities of estriol for the ERα and ERβ relative to those of estradiol are 14% and 21%, respectively. As such, unlike estradiol (and estrone), estriol has preferential affinity  for ERβ.However, estriol is described as a relatively weak estrogen and has mixed agonist-antagonist activity at the ER; on its own, it is weakly estrogenic, but in the presence estradiol, it is antiestrogenic. Relative to estradiol, estriol has 80-fold lower estrogenic potency while estrone has 12-fold lower estrogenic potency.

GPER antagonist

Estriol also acts as an antagonist of the GPER, where, conversely, estradiol acts as an agonist.Estradiol increases breast cancer cell growth via activation of the GPER (in addition to the ER), and estriol has been found to inhibit estradiol-induced proliferation of triple-negative breast cancer cells through blockade of the GPER.

 

Medical use


Estriol is marketed widely in Europe and elsewhere throughout the world under the brand names Ovestin, Ortho-Gynest, and a variety of others. It is available in oral tablet, vaginal cream, and vaginal suppository form, and is used in hormone replacement therapy for menopausal symptoms. Estriol is also available in some countries as estriol succinate (brand name Synapause), a dosage-equivalent ester prodrug of estriol. Estriol and estriol succinate are not approved for use in the United States and Canada, although they have been produced and sold by compounding pharmacies in North America for use as a component of bioidentical hormone replacement therapy. In addition, topical creams containing estriol are not regulated in the U.S. and are available over-the-counter.

 

USP Grade 99% HPLC Estriol Active Pharmaceutical Ingredient CAS 50-27-1 0

 

Contact Details
Hubei Vanz Pharm Co.,ltd

Contact Person: Ms. Wendy Wang

Tel: +86 15927784577

Fax: 86-27-84492310

Send your inquiry directly to us